J Caring Sci. 2018;7(4): 205-211.
doi: 10.15171/jcs.2018.031
PMID: 30607361
PMCID: PMC6311625
  Abstract View: 2270
  PDF Download: 975

Original Research

Impact of Hypericum Perforatum Ointment on Perineal Pain Intensity Following Episiotomy: a Randomized Placebo-Controlled Trial

Farzaneh Vakili 1 ORCID logo, Mandana Mirmohammadaliei 1* ORCID logo, Ali Montazeri 2 ORCID logo, Mina Farokhi 1 ORCID logo, Mohammad Bagher Minaee 3* ORCID logo

1 Department of Midwifery, Faculty of Nursing and Midwifery, Tehran University of Medical Sciences, Tehran, Iran
2 Department of Mental Health, Institute of Health Sciences, Tehran, Iran
3 Department of Histology, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran
*Corresponding Authors: Email: mirmohamad1@yahoo.com; Email: minaezb@sina.tums.ac.ir


Introduction: The present study was conducted to evaluate the effects of Hypericum Perforatum ointment on perineal pain intensity following episiotomy among primiparous women. Methods: This triple-blind clinical trial was performed on 98 eligible primiparous women referring to selected educational hospital of Tehran University of Medical Sciences for normal vaginal delivery. Block Randomization (in 1; 1 ratio) was used to categorize the participants continuously into two groups: intervention (using Hypericum Perforatum ointment) and control (using placebo ointment). Participants in each group used ointments (about 3 grams each time) on episiotomy site, twice a day and for a period of ten days. Our primary outcome was the pain intensity in different intervals following episiotomy. The data were analyzed by SPSS software (version 13) using student's t test, Mann-Whitney U test and chi-square test. Results: We missed 14 participants during the study and analyzed the data from 42 participants in each group. The mean of pain scores revealed no significant differences before (mean difference=-0.33; P=0.46) and four hours (mean difference=0.57; P=0.13) after ointments use, between the intervention and control groups, while these differences were significant after eight hours (mean difference=2.17; P<0.001), five days (mean difference=2.20; P<0.001) and ten days (mean difference=2.21; P<0.001) following the intervention. Conclusion: Using Hypericum Perforatum ointment as a noninvasive, simple and effective topical formulation, can significantly reduce pain intensity of episiotomy site.

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Submitted: 28 Feb 2018
Revision: 27 Apr 2018
Accepted: 22 Oct 2018
ePublished: 22 Oct 2018
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