J Caring Sci. 2019;8(4): 199-206.
doi: 10.15171/jcs.2019.028
PMID: 31915621
PMCID: PMC6942649
  Abstract View: 118
  PDF Download: 131

Original Research

The Effect of Sedation Protocol Using Richmond AgitationSedation Scale (RASS) on Some Clinical Outcomes of Mechanically Ventilated Patients in Intensive Care Units: a Randomized Clinical Trial

Zahra Taran 1 ORCID logo, Masoumeh Namadian 2 * ORCID logo, Soghrat Faghihzadeh 3 ORCID logo, Taraneh Naghibi 4 ORCID logo

1 Department of Nursing, Nursing & Midwifery School, Zanjan University of Medical Sciences, Zanjan, Iran
2 Social Determinants of Health Research Center, Zanjan University of Medical Sciences, Zanjan, Iran
3 Department of Epidemiology and Biostatistics, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran
4 Department of Anesthesiology and Critical Care Medicine, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran


Introduction: Providing for patients’ comfort and reducing their pain is one of the important tasks of health care professionals in the Intensive Care Unit (ICU). The current study was conducted to determine the effect of a protocol using a Richmond Agitation-Sedation Scale (RASS) on some clinical outcomes of patients under mechanical ventilation (MV) in 2017.

Methods: This single-blind clinical trial was conducted on 79 traumatic patients in the ICU who were randomly allocated into the intervention (N=40) and the control groups (N=39). The sedation was achieved, using a sedation protocol in the intervention group and the routine care in the control group. The clinical outcomes of the patients (duration of MV, length of staying in ICU, final outcome) were measured. As the participants had different lengths of MV and staying in ICU, the data were restructured, and were analyzed, using proper statistical methods.

Results: The patients’ level of sedation in the intervention group was significantly closer to the ideal score of RASS (-1 to +1). The duration of MV was significantly reduced in the intervention group, and the length of stay in the ICU was also significantly shorter. There was no difference in terms of final outcome. The ICU cost in the control group was twice as high as the cost in of the intervention group.

Conclusion: The applied sedation protocol in this study would provide better sedation and could consequently lead to significantly better clinical outcomes, and the cost of caring as a result.

Keywords: Clinical trial, Mechanical ventilation, Intensive care unit, Sedation
Citation: Taran Z, Namadian M, Faghihzadeh S, Naghibi T. The effect of sedation protocol using Richmond agitation-sedation scale (RASS) on some clinical outcomes of mechanically ventilated patients in intensive care units. J Caring Sci 2019; 8 (4): 199-206. doi:10.15171/jcs.2019.028
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Submitted: 04 Aug 2018
Accepted: 11 Oct 2018
ePublished: 01 Dec 2019
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