Tabriz University of Medical Sciences Journal of Caring Sciences 2251-9920 7 4 2018 12 01 Impact of Hypericum Perforatum Ointment on Perineal Pain Intensity Following Episiotomy: a Randomized Placebo-Controlled Trial 205 211 10.15171/jcs.2018.031 EN Farzaneh Vakili https://orcid.org/0000-0001-8415-3036 Mandana Mirmohammadaliei https://orcid.org/0000-0002-9145-4723 Ali Montazeri https://orcid.org/0000-0002-5198-9539 Mina Farokhi https://orcid.org/0000-0002-5924-761X Mohammad Bagher Minaee https://orcid.org/0000-0002-3083-540X Journal Article 10.15171/jcs.2018.031 2018 02 28 2018 10 22 Introduction: The present study was conducted to evaluate the effects of Hypericum Perforatum ointment on perineal pain intensity following episiotomy among primiparous women. Methods: This triple-blind clinical trial was performed on 98 eligible primiparous women referring to selected educational hospital of Tehran University of Medical Sciences for normal vaginal delivery. Block Randomization (in 1; 1 ratio) was used to categorize the participants continuously into two groups: intervention (using Hypericum Perforatum ointment) and control (using placebo ointment). Participants in each group used ointments (about 3 grams each time) on episiotomy site, twice a day and for a period of ten days. Our primary outcome was the pain intensity in different intervals following episiotomy. The data were analyzed by SPSS software (version 13) using student's t test, Mann-Whitney U test and chi-square test. Results: We missed 14 participants during the study and analyzed the data from 42 participants in each group. The mean of pain scores revealed no significant differences before (mean difference=-0.33; P=0.46) and four hours (mean difference=0.57; P=0.13) after ointments use, between the intervention and control groups, while these differences were significant after eight hours (mean difference=2.17; P<0.001), five days (mean difference=2.20; P<0.001) and ten days (mean difference=2.21; P<0.001) following the intervention. Conclusion: Using Hypericum Perforatum ointment as a noninvasive, simple and effective topical formulation, can significantly reduce pain intensity of episiotomy site.