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J Caring Sci. 2019;8(1): 17-21. doi: 10.15171/jcs.2019.003
PMID: 30915309        PMCID: PMC6428164

Original Research

The Effect of Aromatherapy by Lavender Oil on Infant Vaccination Pain: a Double Blind Randomized Controlled Trial

Farideh Vaziri 1 * ORCID, Maryam khosropoor 2 ORCID, Mojtaba Hidari 3 ORCID, Saeedeh Pourahmad 4 ORCID, Bahar Morshed Behbahani 1 ORCID, Forough Saki 5 ORCID

Cited by CrossRef: 15

1- ZOR M, ŞİMŞEK KÜÇÜKKELEPÇE D, GÖLBAŞI Z. Türkiye’de aromaterapinin etkisine yönelik yapılan hemşirelik tezlerinin incelenmesi. 2021;12(1):77 [Crossref]
2- Rani R, Sharma S. Recent advances in medicinal applications of essential oil. Materials Today: Proceedings. 2022;68:891 [Crossref]
3- Kolukisa T, Cinar N, Eroglu A, Karakaya Suzan O, Sengun R, Bektas M. The effect of breast milk and other odor interventions applied during venous procedures in the neonatal intensive care unit on the pain and comfort level of premature neonate: Systematic review and meta-analysis. Journal of Neonatal Nursing. 2025;31(3):101625 [Crossref]
4- Re L, Aloia V, Rippa S, Cartabia C, Tommasi V, Ripari C, Marotta S, Bassola B, D’Elia M. Efficacy of Aromatherapy on Children: A Systematic Review with Meta-Analysis. Qeios. 2025;7(4) [Crossref]
5- Usta C, Tanyeri-Bayraktar B, Bayraktar S. Pain Control with Lavender Oil in Premature Infants: A Double-Blind Randomized Controlled Study. The Journal of Alternative and Complementary Medicine. 2021;27(2):136 [Crossref]
6- Razaghi N, Aemmi S, Sadat Hoseini A, Boskabadi H, Mohebbi T, Ramezani M. The effectiveness of familiar olfactory stimulation with lavender scent and glucose on the pain of blood sampling in term neonates: A randomized controlled clinical trial. Complementary Therapies in Medicine. 2020;49:102289 [Crossref]
7- Czarnecki M, Michlig J, Norton A, Stelter A, Hainsworth K. Use of Aromatherapy for Pediatric Surgical Patients. Pain Management Nursing. 2022;23(6):703 [Crossref]
8- Maya-Enero S, Candel-Pau J, Valle-Del Barrio B, Fàbregas-Mitjans M, Prieto-Paja S, López-Vílchez M. Is Inhaled Colostrum as Effective as Inhaled Lavender Essential Oil for Pain Control in Neonatal Frenotomies? A Prospective, Randomized Clinical Trial. Children. 2025;12(8):982 [Crossref]
9- Dewanjee S, Sohel M, Hossain M, Ansari F, Islam M, Sultana F, Al Mamun A, Islam M, Amin M. A comprehensive review on clinically proven natural products in the management of nerve pain, with mechanistic insights. Heliyon. 2023;9(5):e15346 [Crossref]
10- Maya-Enero S, Fàbregas-Mitjans M, Llufriu-Marquès R, Candel-Pau J, Garcia-Garcia J, López-Vílchez M. Analgesic effect of inhaled lavender essential oil for frenotomy in healthy neonates: a randomized clinical trial. World J Pediatr. 2022;18(6):398 [Crossref]
11- Nascimento J, Gonçalves V, Souza B, Nascimento L, Carvalho B, Ziegelmann P, Goes T, Guimarães A. New approaches to the effectiveness of inhalation aromatherapy in controlling painful conditions: A systematic review with meta-analysis. Complementary Therapies in Clinical Practice. 2022;49:101628 [Crossref]
12- Maya-Enero S, Fàbregas-Mitjans M, Llufriu-Marquès R, Candel-Pau J, Garcia-Garcia J, López-Vílchez M. Comparison of the analgesic effect of inhaled lavender vs vanilla essential oil for neonatal frenotomy: a randomized clinical trial (NCT04867824). Eur J Pediatr. 2022;181(11):3923 [Crossref]
13- Ardahan Akgül E, Karakul A, Altın A, Doğan P, Hoşgör M, Oral A. Effectiveness of lavender inhalation aromatherapy on pain level and vital signs in children with burns: a randomized controlled trial. Complementary Therapies in Medicine. 2021;60:102758 [Crossref]
14- 侯 凤. Effect of Olfactory Stimulation of Breast Milk on Neonatal Operational Pain and Feeding: A Meta-Analysis. ACM. 2022;12(10):9403 [Crossref]
15- Kilic F, Kocak H, Kaplan Serin E. Traditional practices in the treatment of children with diaper dermatitis. Journal of Tissue Viability. 2024;33(2):190 [Crossref]
16- Maddocks W. Aromatherapy in Nursing and Midwifery Practice: A Scoping Review of Published Studies Since 2005. J Holist Nurs. 2023;41(1):62 [Crossref]
17- Askarinia S, Razban F, Nematollahi M, Mangolian Shahrbabaki P. Comparing the effect of aromatherapy with breast milk, Lavandula stoechas, and Rosa damascena on venipuncture pain in preterm infants. EXPLORE. 2024;20(2):206 [Crossref]
18- Tüzün Özdemir S, Akyol A. Effect of inhaler and topical lavender oil on pain management of arteriovenous fistula cannulation. J Vasc Access. 2023;24(3):465 [Crossref]