Abstract
            Introduction: E-learning is increasingly replacing traditional methods in medical science  education. The main purpose of this study is to identify opportunities, threats and required  components of E-learning in nursing education.  
  Methods: We conducted a comprehensive systematic review following Preferred Reporting  Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines, searching Web of Science,  Scopus, ProQuest, Cochrane Library, ScienceDirect, Medline/PubMed, Google Scholar, and SID,  Irandoc, and Magiran databases without time or language restrictions. Two researchers assessed  each systematic review using A Measurement Tool to assess systematic Reviews (AMSTAR). This  overview includes 47 reviews published until the end of 2022.  
  Results: Electronic education in nursing offers opportunities categorized into 10 areas: accessibility  and flexibility, efficiency and effectiveness, strengthening clinical competencies, features of  electronic education, improving educational processes, improving the quality of education,  evaluation and feedback, diversity and practically of content, setting learning environment and  promotion of nursing professors’ role. However, there are also challenges, grouped into 10  categories: challenges of evaluation and feedback, problems related to the of human resources  development, structural and technical limitations, challenges related to communication and  interaction, challenges related to the content of education, financial challenges, organizational  challenges, cultural challenges, challenges of professional competence, challenges of ethics  and information security. The essential components for effective electronic teaching in nursing  education are organized into 6 categories: technological infrastructure, human infrastructure,  pedagogical infrastructure, cultural and social infrastructure, economic infrastructure, and  management and leadership infrastructure.  
  Conclusion: E-learning offers an efficient and effective training method for nurses that should be  embraced given advances in science and technology. Addressing infrastructure limitations will  further enhance its benefits.